Objective To explore the effect of acupoint massage combined with tooth tapping and saliva swallowing therapy premised upon the core symptom on digestive symptom cluster in patients with gastric cancer undergoing chemotherapy after surgery.Me-thods A total of 114 patients with gastric cancer undergoing chemotherapy after surgery were randomly divided into a control group, experimental group Ⅰ, and experimental group Ⅱ, with 38 participants in each group.All three groups received routine treatment.On this basis, participants in experimental group Ⅰ received acupoint massage therapy premised upon core symptom, while participants in experimental group Ⅱ received acupoint massage combined with tooth tapping and saliva swallowing therapy premised upon core symptom.The treatment course lasted 3 weeks.After the end of the treatment course, the severity of core symptom （taste alteration） and other symptoms within the symptom cluster before and after treatment were compared among the three groups.Results The inter-group effect, time effect, and interaction effect of chemotherapy-related taste alteration scores among the three groups were significant.The chemotherapy-related taste alteration scores for both the experimental group Ⅰ and experimental group Ⅱ were lower than those of the control group during the first, second, and third weeks post-chemotherapy （P＜0.05）,with the lowest scores observed in experimental group Ⅱ.Additionally, the inter-group effect, time effect, and inte-raction effect for appetite loss, dry mouth, sensation of fullness, nausea, and vomiting scores were also significant. In the second and third weeks post-chemotherapy, the scores for appetite loss, dry mouth, sensation of fullness, nausea, and vomiting in experimental group Ⅰ and experimental group Ⅱ were all lower than those of the control group （P＜0.05 for both）.Furthermore, the scores for appetite loss and dry mouth in experimental group Ⅱ were lower than those in experimental group Ⅰ （P＜0.05 for both）.Conclusion Acupoint massage combined with tooth tapping and saliva swallowing therapy premised upon the core symptom could better control the digestive symptom cluster for patients undergoing chemotherapy after gastric cancer surgery, and improve the efficacy and precision of symptom management.