This article summarizes the perioperative nursing experience of a patient with severe burns who underwent xenogeneic skin transplantation using genetically edited pig skin.The key nursing points for this case included timely and standardized fluid resuscitation, active prevention and treatment of burn-related infections, close monitoring of the patient′s condition to identify xenograft rejection early, and comprehensive psychological intervention to promote a positive mental state, overcoming psychological barriers to facilitate cooperation with the xenogeneic skin graft treatment.After 130 days of careful assessment and dedicated nur-sing care, the patient was rehabilitated and discharged.