Objective To explore the effectiveness of a nurse-led multidisciplinary team in the prevention and management of deep venous thrombosis (DVT) in children with severe Mycoplasma pneumonia.Methods A quasi-experimental research design was employed.A total of 95 children with severe Mycoplasma pneumonia hospitalized within the period from August to November 2023 as the control group, who received routine preventive nursing care for DVT.From December 2023 to March 2024, 90 children were included in the intervention group, where a nurse-led multidisciplinary team implemented DVT prevention and management interventions.The incidence of hospital-acquired DVT and length of hospital stay were compared between the two groups.Results The incidence of hospital-acquired DVT in the intervention group was significantly lower than that in the control group (P＜0.05).Additionally, the length of hospital stay in the intervention group was shorter than that in the control group (P＜0.05).Conclusion A nurse-led multidisciplinary team effectively reduces the incidence of hospital-acquired DVT and length of stay in children with severe Mycoplasma pneumonia, providing new insights for early identification and management of DVT risk in critically ill children.