Objective To explore the effectiveness of a caregiving skills training program for caregivers of disabled older adults based on Van Houtven′s organizing framework for caregiver interventions. Methods Based on Van Houtven′s organizing framework for caregiver interventions, a comprehensive caregiving skills training program for caregivers of disabled older adults were developed, including clinical caregiver skills, psychological caregiver skills and support seeking skills. From October 2023 to May 2024, 80 family caregivers of disabled older adults admitted to hospital for medical problems were randomized into two groups, with 40 in each. The control group was givenusual care and follow-ups after discharge, while the intervention group additionally received the caregiving skills training program for 4 weeks. Caregiving skills and caregiver burden of family caregivers, as well as quality of life of disabled older adults were assessed before and immediately after the intervention. Results Immediately after the intervention, the intervention group had significantly increased caregiving skills of the caregivers, decreased caregiver burden, and higher quality of life of the disabled elderly compared to the control group （all P<0.05）. Conclusion The comprehensive caregiving skills training program for caregivers of disabled older adults based on the Van Houtven′s framework can effectively enhance caregiving skills of caregivers, reduce their caregiver burden, and improve quality of life of the disabled elderly.