Objective To develop a question prompt list (QPL) for self-management in patients with polycystic ovary syndrome (PCOS), and to an provide effective aid for this population to actively obtain self-management related information. Methods A QPL for self-management was developed based on literature review, semi-structured interviews, and Delphi expert consultation. A convenience sample of 45 patients with PCOS were invited to evaluate the clinical feasibility of the QPL. Results A total of 18 experts completed two rounds of expert consultation. The response rate was 90% (18/20 experts) in round one and 100% (18/18 experts) in round two. The coefficients of expert authority were 0.950 and 0.947, respectively. In round two, the Kendall′s coefficient of concordance (W) for item importance was 0.202 (P<0.05). The QPL included 7 primary indicators and 46 secondary indicators. Conclusion This QPL is comprehensive and practical, which facilitates patients to ask more targeted questions about self-management, resulting in improving the efficiency of doctor-patient communication, meeting their individual needs, and enhancing their self-management ability.