Objective To investigate the level and factors associated with job crafting in novice head nurses in tertiary hospitals, and to provide reference for targeted intervention. Methods A convenience sample of 239 novice head nurses were recruited from 15 tertiary hospitals in Shandong Province and were invited to complete a battery of questionnaires, including a demographic questionnaire, the Job Crafting Scale, the Family Support Scale, the Connor-Davidson Resilience Scale, the Revised version of Nursing Research Capacity of Self-evaluation Questionnaire, and the Nursing Informatics Competency Assessment Tool. Results The sample scored (55.49±20.94) points for job crafting. Multiple linear regression showed that gender, education level, family support, psychological resilience, nursing research capacity, and informatics competency were the influencing factors of job crafting (all P<0.05). Conclusion Job crafting of novice head nurses in tertiary hospitals is at a low to moderate level and affected by various factors. It is recommended that nursing administrative managers pay more attention to female novice head nurses and those with bachelor′s degree, enhance their nursing research capacity and informatics competency, psychological resilience, and family support, resulting in improving their job crafting behaviors.