Objective To reform the experimental teaching of Fundamentals of Nursing in the perspective of ideological and political theory education based on the concept of full integration of soft and hard skills, and to evaluate the implementation effects. Methods Ninety-two undergraduate nursing students enrolled in 2021 from the Institute of Medicine and Nursing were selected as a control group, who were traditionally taught in Fundamentals of Nursing experimental teaching; and eighty-five undergraduate nursing students enrolled in 2022 were selected as an intervention group,their teaching content and methods were designed based on the concept of full integration of soft and hard skills in the perspective of ideological and political theory education, and mixed teaching methods were employed to enhance their soft skills such as clinical thinking, humanistic caring, communication, teamwork, problem analysis and solving, etc. Results In the skills examination, the intervention group achieved higher total score, hard skills score and feedback indicators score, and its soft skills scores such as communication, humanistic caring, and clinical thinking were significantly higher than those of the control group (all P<0.05), and the evaluation of 7 aspects of teaching methods by the intervention group were significantly better than those of the control group (all P<0.05). Conclusion The experimental teaching of Fundamentals of Nursing with full integration of soft and hard skills in the perspective of ideological and political theory education is conducive to improving students′ hard and soft skills, achieving the organic integration of professional education and ideological and political theory education.