This paper summarized the experience of perioperative emergency nursing for a patient with severe coagulation disorders secondary to acute fatty liver of pregnancy.The key points of nursing included early identification of acute fatty liver of pregnancy, establishment of a multidisciplinary rapid response team; correction of coagulation disorders and maintenance of internal environment stability; dynamic assessment of disease changes and active prevention and treatment of postoperative complications; provision of psychological nursing throughout the whole process and personalized life support, providing breastfeeding guidance to patients and ensuring follow-up care.After active treatment and meticulous nursing by the multidisciplinary team, the patient was successfully treated and discharged smoothly.After a 6-month follow-up, the mother and her twin babies were in good condition.