Objective To develop and test the reliability and validity of a scale measuring the coping resources for nursing interruptions.Methods Guided by six types of resources of the Conservation of Resources theory, a draft scale was developed through literature review, semi-structured interviews, Delphi consultation, and a pilot survey.Then a convenience sample of 547 nurses were selected from a tertiary hospital in Hubei Province and a tertiary hospital in Xizang Autonomous Region to test the reliability and validity of the scale.Results Five factors were identified through exploratory factor analysis, accounting for 88.211% of the total variance, and confirmatory factor analysis indicated a well-fitting model （χ2/df=2.776,RMSEA=0.058,CFI=0.961,NFI=0.940, and TLI=0.955）.The formal scale included 26 items contributing to 5 dimensions:key resources, constructive resources, energies resources, macro resources, and social support.The scale-level content validity index (CVI) was 0.980 and the item-level CVI ranged from 0.923 to 1.000.The overall Cronbach′s α coefficient was 0.985 and the test-retest reliability was 0.932.Conclusion This scale is valid and reliable for measuring nurses′ coping resources in the process of nursing interruptions.