Objective To identify profiles of health problem solving in type 2 diabetes patients with comorbid metabolic syndrome, to analyze the influencing factors and compare self-management behavior, blood glucose and lipid parameters between different profiles, so as to provide reference for enhancing their health problem solving and outcomes.Methods A convenience sample of 225 patients were surveyed using a general information questionnaire, the Health Problem Solving Scale, the Self-management Know-ledge, Attitude and Practice Scale for Metabolic Syndrome, the Short-form Chronic Disease Self-Efficacy Scale, the Connor-Davidson Resilience Scale and the Health Information Literacy Self-rating Scale.Latent profile analysis was performed to identify subgroups of health problem solving, and logistic regression was used to analyze the influencing factors of different subgroups.Self-management behavior, blood glucose and lipid parameters were compared between different subgroups.Results Two profiles were found: effective health problem solving （72.0%） and ineffective health problem solving （28.0%）.Self-efficacy, resilience and health information literacy were factors affecting profiles of health problem solving (all P＜0.05).Patients with effective health problem solving had better self-management behaviors, fasting blood glucose, glycosylated hemoglobin A1c, and high-density lipoprotein cholesterol compared to those with ineffective health problem solving (all P＜0.05).Conclusion Type 2 diabetes patients with comorbid metabolic syndrome display distinct patterns of health problem solving.Interventions on improving self-efficacy, resilience, and health information literacy could be conducted to cultivate effective health problem solving, thus to enhance patients′ self-management behaviors and achieve glycemic and lipid control.