Objective To explore the application effect of information management platform combined with wearable devices in the management of chronic kidney disease. Methods A chronic kidney disease management platform was developed, and a chronic kidney disease management team was established. A total of 90 patients with chronic kidney disease stage Ⅰ-Ⅲ were randomly divided into intervention group A, group B and control group of 30 cases each. The control group received routine health management, intervention group A was managed on the basis of routine management with the inclusion of the information management platform, and intervention group B was implemented the health management interventions by combining wearable devices (multifunctional health smart bracelets) on the basis of intervention group A. After 6 months, the differences of disease management ability, laboratory indicators and blood pressure compliance rate among the three groups were compared. Results A total of 30 cases in the control group，29 cases in the intervention group A, and 28 cases in the intervention group B completed the whole study. After 6 months of follow-up, the differences in self-management ability scores among the three groups were significant; compared pairwise, the control group was significantly lower than the intervention group A and B, and the intervention group A was significantly lower than the intervention group B (all P<0.05). The differences in hemoglobin values among the three groups were statistically significant; compared pairwise, the control group was significantly lower than the intervention group A (both P<0.05). The endogenous creatinine clearance rates among the three groups were statistically significant; compared pairwise, the control group was significantly lower than the intervention group B (both P<0.05). The blood pressure compliance rates among the three groups were statistically significant; compared pairwise,the control group was significantly lower than the intervention group B, the intervention group A was significantly lower than the intervention group B (all P<0.167). Conclusion The management of chronic kidney disease patients through the information management platform combined with wearable devices can significantly improve patients′ self-management ability and delay disease progression.