Objective To construct a safe medication management map for chronic disease patients in the community based on the concept of traveler′s map and verify its validity and feasibility, so as to further standardize the medication-taking behavior of chronic disease patients in the community, improve their medication adherence, and reduce the incidence of adverse medication events. Methods A total of 40 chronic disease patients from 2 communities in Guiyang city were randomly divided into 20 cases each in the control group and the observation group. The control group received conventional safe medication management. The research team formed a visualized safe medication management traveler map by discussing, revising, and setting the development scenario and user roles of the traveler map, and used the traveler map in the observation group patients′ medication management. The intervention lasted for 3 months. The scores of medication adherence, rational medication self-efficacy, and knowledge of safe medication use between the two groups were compared. Results Twenty cases in the control group and 19 cases in the observation group completed the study. The scores of medication adherence, rational medication self-efficacy, and knowledge of safe medication use in the observation group were significantly better than those of the control group (all P<0.05). Conclusion The safe medication management map based on the traveler′s map, through the visual presentation of the patient as the "core player", leverages patients′ proactivity to actively engage in the medication management, which to a certain extent improves patients′ medication adherence, increases self-efficacy of rational medication-taking and promotes mastery of knowledge of safe medication-taking.