Objective To determine the latent profiles of social alienation in psoriasis patients and their relations to anxiety and depression, so as to provide reference for conducting targeted measures to promote patients′ mental health.Methods A convenience sample of 376 psoriasis patients were invited to fill out a general information questionnaire, the General Alienation Scale, the Distress Disclosure Index, and the Hospital Anxiety and Depression Scale.Latent profile analysis was performed to identify classes of social alienation and the influencing factors were also analyzed, then anxiety and depression scores of patients in different classes of social alienation were compared.Results Three classes were identified:a moderate class (73.4%), a high alienation and uncertainty class (18.6%) and a low alienation and meaninglessness class (8.0%).Personal monthly income, duration of illness, whether skin lesions exposed or not, size of skin lesions, presence of itching, and distress disclosure level were the influencing factors of profiles of social alienation (all P＜0.05).The anxiety and depression scores had significant differences among the 3 classes (both P＜0.05).Conclusion There is heterogeneity in social alienation in psoriasis patients, and those with high social alienation have relatively higher levels of anxiety and depression.Targeted interventions should be carried out according to the influencing factors, thus to promote their psychological health.