Objective To develop an intelligent surgical safety check process and to evaluate its effectiveness.Methods A total of 11,204 operations performed from August to October 2023 were given routine surgical safety check, while 11,012 operations performed from November 2023 to January 2024 received an intelligent check system for ensuring patient safety during the entire surgical process.Results The rate of standard surgical safety check was significantly improved, whereas the incidence of potential adverse patient events was significantly decreased after applying the intelligent check system for process optimization （both P＜0.05）.Conclusion The design and implementation of an intelligent surgical safety check system can effectively standardize check process, reduce potential adverse patient events, and ensure safety of surgical patients.