Objective To summarize the best evidence regarding patient self-management following left ventricular assist device (LVAD) implantation, and to provide evidence for health education and patient self-management.Methods A systematic literature search was performed to identify relevant literature on patient self-management after LVAD implantation across various guideline websites, bibliometric databases, and websites of professional organizations and societies.The search time frame was from the inception of the database to April 30, 2024.Two researchers independently evaluated the quality of the literature and extracted data, then integrated the evidence, with the assistance of professional judgment.Results Eleven publications were eligible, including 5 clinical decision support statements, 3 guidelines, 1 expert consensus report, and 2 randomized clinical trials.A total of 51 pieces of best evidence were summarized, covering 7 topics:knowledge related to equipment management, living environment and lifestyle, exercise rehabilitation, nutrition and body weight management, prevention of complications, psychosocial support, and discharge follow-up.Conclusion The best evidence summarized for self-management in patients after LVAD implantation is scientific and practical, enabling nursing staff to guide patients′ self-management behaviors in a more standardized and evidence-based manner.