Objective To develop and implement a non-pharmacological intervention program for post-burn pruritus, to reduce pruritus severity and improve quality of life of patients.Methods A total of 78 patients with post-burn pruritus were chronologically divided into a control group of 40 and an intervention group of 38.The control group was given routine nursing care, while the intervention group received non-pharmacological interventions which were formulated through evidence synthesis and two rounds of Delphi expert consultation.After 2 weeks of intervention, pruritus score, pruritus severity, the incidence of skin lesions secondary to a scratching behavior and quality of life were compared between the two groups.Results The intervention group had significantly lower pruritus score, pruritus severity and quality of life score compared with the control group （all P＜0.05）.There was no significant difference in the incidence of skin lesions secondary to a scratching behavior between the two groups （P＞0.05）.Conclusion The implementation of non-pharmacological intervention program for post-burn pruritus can reduce pruritus severity and improve quality of life of patients.