Objective To investigate the level of social integration in young and middle-aged patients with chronic heart failure, and to analyze the influencing factors.Methods A convenience sample of 307 hospitalized young and middle-aged patients with chronic heart failure were recruited and invited to complete a battery of questionnaires, including a demographic questionnaire, the Berkman-Syme Social Network Index, the Anxiety Measure of the Existential Meaninglessness Scale,the Family APGAR Index,and the Brief 2-Way Social Support Scale.Results The total social integration score was （6.60±2.26）, with 91（29.64%） patients at Grade Ⅰ, 62（20.20%） at Grade Ⅱ, 98（31.92%） at Grade Ⅲ, and 56（18.24%） at Grade Ⅳ.Ordinal logistic regression analysis showed that, age, duration of heart failure, left ventricular ejection fraction, comorbidity index, meaninglessness-anxiety, family function, and bidirectional social support were factors influencing social integration in young and middle-aged patients with chronic heart failure（all P＜0.05）.Conclusion Young and middle-aged patients with chronic heart failure report low level of social integration, which is affected by a variety of factors.Health care professionals should develop individualized strategies targeted to the modifiable factors to promote social integration of patients and avoid social isolation.