Objective To develop an information system for use by nursing staff in managing breast cancer-related lymphedema，and to evaluate its usability. Methods The information system for breast cancer-related lymphedema was developed based on the User Experience Elements Model. A total of 42 members of the breast cancer-related lymphedema care team were invited to evaluate the system′s usability using the System Usability Scale (SUS). Results The breast cancer-related lymphedema information system consists of four major modules: information registration, information retrieval, data statistics, and clinical research. The overall usability score, as rated by the lymphedema care team members, was (83.11±10.86) points. Conclusion The breast cancer-related lymphedema information system based on the User Experience Elements Model has good usability, providing comprehensive management support throughout the entire care cycle for nursing staff and patients with lymphedema.