Objective To explore the characteristics of endotracheal intubation-related pressure injury in ICU patients, and to analyze its influencing factors. Methods A total of 713 ICU patients with indwelling tracheal intubation were selected, and they were divided into an injury group (n=290) and a non-injury group (n=423) according to whether tracheal intubation-related PI occurred. The clinical data and endotracheal intubation-related data were compared between the two groups. Logistic regression was used to analyze the influencing factors of endotracheal intubation-related pressure injury in ICU patients. Results Endotracheal intubation-related PI occurred in 290 patients, with an incidence of 40.67%. Logistic regression analysis showed that APACHE Ⅱ score, interleukin-6, prone ventilation, analgesia, and duration of endotracheal intubation were risk factors for endotracheal intubation-related PI in ICU patients, and lower degree of skin humidity and higher serum albumin levels were protective factors (all P<0.05). The constructed logistic regression model had an AUC=0.948 (95%CI:0.933-0.963)， and good model fit. Conclusion The incidence of endotracheal intubation-related PI in ICU patients is high, and clinical attention should be paid to its influencing factors and targeted interventions should be formulated to reduce the incidence of endotracheal intubation-related PI.