The perioperative nursing experience of a patient who underwent thoracoscopy combined with right thoracotomy sleeve style left total pulmonary resection under extracorporeal membrane oxygenation support was summarized. Preoperative nursing included guidance of respiratory functional exercise and actively control of infections, assessment of potential postoperative complications and implementation of predictive care. Postoperative nursing included comprehensive assessment of respiratory system risks, personalized implementation of airway management, management of safe position to prevent poor healing of tracheal anastomosis, balancing postoperative inflow and outflow to prevent cardiovascular complications, multidimensional pain management, persona-lized development and implementation of rehabilitation exercise plans, paying attention to coagulation function and preventing complications such as bleeding and thrombosis, control of infection, promoting surgical incision healing, paying attention to recurrent laryngeal nerve injury and rehabilitation to improve long-term quality of life. After intensive perioperative care, the patient recovered smoothly and was discharged on the 8th day after surgery. After 3 months of follow-up, the patient′s recovery was good.