The post-thrombotic syndrome (PTS) of deep veins is a long-term chronic complication after the deep vein thrombosis (DVT), which significantly impacts patients′ prognosis and quality of life.This manuscript offers a comprehensive review of stra-tegies aimed at preventing PTS in patients with DVT, and outlines the current methods applied in the care and management of PTS, in order to provide references for early prevention of the early prevention of PTS and improvement of prognosis of the affec-ted patients.