Objective To explore the application value of 5G+ pre-hospital and in-hospital integrated fusion system in the treatment of severe trauma patients in emergency department.Methods A total of 65 patients with severe trauma admitted to the emergency department from January to June 2023 were selected as the control group, and 69 patients with severe trauma admitted from July to December of the same year were selected as the observation group.The control group recived the traditional trauma treatment mode, and the observation group recived the 5G+ pre-hospital and in-hospital integrated fusion system trauma treatment mode.The success rate of rescue, early mortality rate, CT completion time, emergency room detention time, preoperative preparation time and total hospital stay of the two groups were compared.Results The success rate of rescue in observation group was significantly higher than that in control group, the early mortality rate was significantly lower than that in control group, and the time of trauma treatment was significantly shorter than that in control group (all P＜0.05).Conclusion The application of 5G+ pre-hospital and in-hospital integrated fusion system can effectively realize the interconnection of pre-hospital and in-hospital trauma treatment, and improve the overall treatment level of severe trauma patients.