Objective To construct multimodal nursing interventions program for patients with mild cognitive impairment （MCI） and evaluate its effectiveness.Methods A convenience sampling method was used to select 80 MCI patients who attended the geriatric psychiatry outpatient clinic of a tertiary care hospital from May to December 2022, and they were divided into a control group and an experimental group according to the patient′s community, with 40 patients in each group.In the control group, routine healthy lifestyle guidance was implemented, and the patients were followed up by telephone once a month.In the experimental group, multimodal nursing interventions were implemented on the basis of the control group, including visual, tactile, auditory, language, gestural and spatial modality training.Before, 3 and 6 months into the intervention, the scores of Montreal Cognitive Assessment-Basic (MoCA-B), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and World Health Organization Quality of Life (WHOQOL-BREF) were compared between the two groups.Results There were 39 cases in the control group and 37 cases in the intervention group that had completed the study.The scores of the MoCA-B and the WHOQOL-BREF were significantly higher than those of the pre-intervention and of the control group at 6 months into the intervention, and the scores of the HAMD and the HAMA were significantly lower than those of the pre-intervention and of the control group (all P＜0.05).Conclusion Multimodal nursing interventions can improve cognitive function, depression and anxiety, and quality of life of MCI patients.