Objective To explore the implementation effect of the intervention of good death care guided by Heart to Heart cards in hospice care for advanced cancer patients. Methods Advanced cancer patients were divided into a control group and an intervention group chronologically, with 70 cases in each group. The control group received routine nursing care, while the intervention group additionally received good death care guided by Heart to Heart cards. After the intervention, the scores of the Questionnaire Quality from the Patient′s Perspective for Palliative Care (QPP-PC) and the Terminally Ill Patients′ Good Dealth Scale (TIPGDS) between the two groups were compared. Results Sixty seven patients in the control group and 65 patients in the intervention group completed the study. After the intervention, the total score of QPP-PC, the total score and each subscale score of TIPGDS in the intervention group were significantly higher than those in the control group (all P<0.05). Conclusion Good death care guided by Heart to Heart cards can meet the expectations and needs of advanced cancer patients to the largest extent, improve their perceived quality of hospice care, enhance their level of good death, finally achieve the goal of good death.