Objective To explore the relationship between readiness to return to work and resourcefulness and fear of disease progression in young and middle-aged patients after percutaneous coronary intervention (PCI), so as to provide a reference for promoting them return to work. Methods A total of 205 young and middle-aged patients one month after PCI were conveniently selected from the cardiovascular outpatient department of a grade three hospital in Shenzhen, then they were investigated by utilizing a general information questionnaire, the Fear of Progression Questionnaire-Short Form, the Chinese version of the Resourcefulness Scale and the Readiness for Return to Work Scale. Results There were 54 patients (26.34%) in the pre-intention stage, 42 patients (20.49%) in the intention stage, 88 patients (42.93%) in the action preparation-self-assessment stage, and 21 patients (10.24%) in the action preparation-action stage in the readiness to return to work. Ordered logistic regression analysis showed that, the older the age, the worse the cardiac function classification, the higher the fear of disease progression, and the lower the resourcefulness of patients after PCI, their readiness to return to work were lower (all P<0.05). Conclusion There is a high proportion of young and middle-aged patients after PCI in the action preparation-self-assessment stage, and fear of disease progression and resourcefulness can predict their readiness to return to work. Medical staff should pay attention to the resourcefulness level of young and middle-aged patients after PCI, reduce the influence of fear of disease progression, and improve their mental health, so as to increase their readiness to return to work.