Objective To form expert consensus on nursing of indwelling double-cavity gastrointestinal nutrition tube for patients with severe neurological diseases, so as to push clinical nurses implement standardized, safe and effective double-cavity gastrointestinal nutrition tube feeding, then to meet the nutritional needs of patients. Methods Relevant evidence on nursing of gastrointestinal nutrition tube for patients with severe neurological diseases was retrieved, evaluated and summarized, and relevant recommendations were extracted to form the preliminary draft of expert consensus, which was modified and improved according to expert opinions through a one-round expert consultation and a two-rounds expert demonstration meeting, then the final draft of expert consensus was developed. Results The final expert consensus consisted of 5 aspects:the operational definition, indications, contraindications, catheterization and maintenance, and extubation of double-cavity gastrointestinal nutrition tube feeding in patients with severe neurological diseases. Conclusion The expert consensus is practical and can provide guidance for clinical nursing practice and quality control of double-cavity gastrointestinal nutrition tube in patients with severe neurological diseases.