Objective To review the application status of non-pharmacological intervention evidence for post-burn itch, to analyze the barriers and promoting factors in the process of evidence transformation, and to develop action strategies to provide references for alleviating post-burn itch. Methods Review indicators were developed according to the 21 pieces of best evidence on non-pharmacological intervention for post-burn itchin from previous studies, then barriers and promoting factors were analyzed by using the evidence application obstacle identification assessment list under the framework of i-PARIHS. Results A total of 23 review indicators were developed, 3 review indicators had a compliance rate >60%, 18 review indicators had a compliance rate <60% (among them,11 review indicators had a compliance rate of 0), and the other 2 indicators did not review relevant patients. The main barriers:the "change" related barriers were that the evidence had not been transformed into usable and accessible form, and the lack of relevant processes was not conducive to clinical nurses to implement the change; the "change recipient" related barriers were insufficient knowledge of nurses, lack of relevant knowledge training, and ignorance of the effectiveness and accuracy of intervention; the "organizational environment" related barriers were the lack of relevant systems, standards, reward and punishment mechanisms, and the lack of supporting equipment and systems. Conclusion There is a big gap between the clinical implementation of non-pharmacological intervention for post-burn itch and the best evidence. Medical staff should actively implement changes to promote the effective application of the best evidence and alleviate post-burn itch.