Objective To design and write an evidence-based manual for popularization of knowledge about acute pancreatitis, and to provide reference for health education.Methods We established a working group, conducted interviews with medical personnel and patients who had acute pancreatitis to clarify patients′ needs for health education, searched electronic databases to summarize the best evidence, translated the evidence into guidance that was understandable by the patient and average citizen, compiled a draft manual in accordance with the principles of popular science works creation, and invited a panel of 6 experts to refine the manual for two rounds.Results The manual was composed of 5 themes.Patient satisfaction rate was 94.23% and public satisfaction rate was 93.33%.Conclusion The patient needs-oriented, evidence-based manual for popularization of knowledge about acute pancreatitis is scientific and practical, and is also well accepted by patients and average citizens.