Objective To investigate the effects of integrating BOPPPS into online/offline blended learning in teaching caring-oriented technical and procedural skills for nursing students.Methods A total of 102 undergraduate nursing students practicing in the vascular surgery department were divided into a control group of 50 and an intervention group of 52 chronologically.The control group was given conventional clinical teaching, while the intervention group received a novel teaching that integrated BOPPPS into online/offline blended learning to teach caring-oriented technical and procedural skills.The Caring Ability Inventory （CAI） and the Lear-ning Motivation Scale were completed by both groups before and after the intervention, and procedural skills test was also performed.Furthermore, evaluation of the novel teaching mode by the intervention group was collected.Results The intervention group had significantly higher caring ability, learning motivation, and performance in procedural skills test compared with the control group （all P＜0.05）.Greater than eighty percent (84.62%-96.15%) of participants in the intervention group had a favorable attitude toward the novel teaching mode.Conclusion Integrating BOPPPS into online/offline blended learning in teaching caring-oriented technical and procedural skills can motivate students to learn, and effectively improve their technical and procedural skills as well as caring ability.