Objective To retrieve relevant evidence on nursing administration of medication via enteral feeding tubes, to summarize and analyze the best evidence, and to provide reference for nursing practice.Methods We searched websites and electronic databases for literature relating to nursing administration of medication via enteral feeding tubes from database inception to 14 August 2023.Two researchers independently assessed eligibility for inclusion and methodological quality of the literature, and three graduate nursing students extracted information from each paper.Results A total of 14 articles met the inclusion criteria, including 6 guidelines, 2 evidence summaries, 3 expert consensus reports, and 3 quasi-experimental studies.A total of 26 pieces of best evidence were summarized, covering 10 aspects:system optimization, pre-administration assessment, preparing the supplies, preparing medication, administrating the medication, flushing the tube, preventing and managing tube occlusion, preventing reflux and aspiration, documentation and effect monitoring, and planning discharge from hospital.Conclusion The summarized evidence can be translated into clinical practice by considering specific clinical situations and patients′preferences, so as to standardize administration of medication via enteral feeding tubes and ensure medication safety.