A total of 25 patients underwent transcatheter edge-to-edge valve repair for tricuspid regurgitation.The experiences of caring for these patients during the operation were summarized, including making preparedness plans for emergency situations for high-risk patients; preparing surgical instruments and clips for valve repair; placing patient at comfortable position based on the characteristics of tricuspid regurgitation; adjusting the operating system to avoid thrombosis and air embolism; monitoring blee-ding complications during heparinization; preventing malignant arrhythmias; implementing goal-directed glycemic control; and preventing clamp dislodgement.Immediately after the operation, the regurgitation grade was decreased, from severe or very severe (grade≥3), to mild (grade 1) in 13 patients, to moderate (grade 2) in 10 patients, and to grade 3 in 2 patients.All patients were discharged in 3 to 7 days after the surgery, and followed-up for 6months.Regurgitation grade was≤3, cardiac function and quality of life were significantly improved.