Objective To construct a diet and exercise program for children with craniopharyngioma-related hypothalamic obesity（CP-HO）, and to provide reference for clinical practice.Methods Following the integrated theory of health behavior change, the draft of diet and exercise program for children with CP-HO was developed through evidence-based literature review and semi-structured interviews.Using Delphi methods, 19 experts were selected to conduct two rounds of consultation to reach a consensus.Results The return rates of questionnaires were 90.48% and 100%, and the expert authority coefficients were 0.89 and 0.90 in the first and second rounds of consultation, respectively.In the second round of consultation, the coefficient of variation (CV) of each index for its importance was 0.06-0.19, and the Kendall′s coefficient of concordance (W) was 0.101 （P＜0.05）;the CV of each index for its feasibility was 0.10-0.23, and the Kendall′s W was 0.122 （P＜0.05）.The final diet and exercise program for children with CP-HO included 4 first-level indexes, 18 second-level indexes, and 44 third-level indexes.Conclusion The constructed diet and exercise program for children with CP-HO is well-accepted by experts and is feasible.Further empirical research is needed to verify the effectiveness.