Objective To retrieve and select relevant evidence on the prevention and management of enteral feeding interruption（EFI） in critically ill patients, and to provide theoretical basis for clinical healthcare professionals to prevent and manage EFI in critically ill patients. Methods We utilized evidence-based nursing methodology to construct nursing questions, and conducted literature search according to the "6S" evidence model across databases like BMJ Best Practice, UpToDate, JBI, the European Society for Clinical Nutrition and Metabolism, the American Society for Parenteral and Enteral Nutrition, Medlive (Guideline Version), PubMed, Web of Science, CNKI, Wanfang Data, and SinoMed, etc. The search was limited to literature published up to June 10, 2023. Two researchers independently evaluated and extracted evidence from the included publications. Results A total of 34 publications were included, from which 23 pieces of best evidence were summarized, covering seven aspects:definition of EFI, timing of starting enteral nutrition, assessment and monitoring of enteral nutrition, causes for EFI, timing of EFI, strategies for prevention and management of EFI, and training and education. Conclusion The best evidence summarized in this study regarding the prevention and management of EFI in critically ill patients can provide a basis for clinical healthcare professionals to analyze causes for EFI and to develop clinical intervention plans for EFI.