Objective To explore the effect of selective radial artery compression on alleviating forearm hematoma in elderly patients undergoing coronary intervention. Methods A total of 152 elderly patients with forearm hematoma after coronary interventional therapy were selected and randomized into 2 groups. The forearm hematoma in the control group (n=76) was compressed with the ordinary cuff of pulse wave multifunctional sphygmomanometer, while the forearm hematoma in the experimental group (n=76) was compressed with a customized hollow cuff with dual airbags. The outcomes of thumb skin temperature, pain score, hand swelling degree, comfort level, heart rate and blood pressure were compared between the two groups during cuff compression. Hand numbness before cuff compression relief, forearm circumference after relief, and the rate of effective compression at the first attempt were also compared. Results During cuff compression, thumb skin temperature, pain score, hand swelling, comfort, heart rate, blood pressure, and hand numbness were better in the experimental group than in the control group (all P<0.05). The forearm circumference，and rate of effective compression at the first attempt had no significant difference between the two groups (both P>0.05). Conclusion Application of a customized dual airbag hollow cuff for selective radial artery compression of forearm hematomas, ensures effective compression of the cuff without blocking the forward blood flow of the ulnar artery and ulnar vein, and improves patients′ comfort during cuff compression.