Objective To explore the effect of applying a sequential traditional Chinese medicine （TCM） exercise scheme in patients receiving hematopoietic stem cell transplantation (HSCT). Methods A total of 44 patients receiving HSCT were enrolled and assigned by using the random number table method into 2 groups of 22 cases each. The control group was subjected to a routine HSCT exercise rehabilitation program, while the intervention group to a sequential TCM exercise rehabilitation program on the basis of the routine program. The results of the Short Physical Performance Battery （SPPB）, the Fatigue Severity Scale (FSS), body mass index (BMI)，Modified Barthel Index (MBI), incidence rates of adverse events and compliance with exercise rehabilitation in the 2 groups were evaluated at varied timepoints. Results At 14 days, and 28 days into HSCT, the results of SPPB score, FSS score, MBI score and compliance with exercise rehabilitation in the intervention group were significantly better than those in the control group (all P<0.05). There were no adverse events occurring during exercise rehabilitation in the 2 groups. Conclusion The sequential TCM exercise scheme for HSCT patients is feasible and safe, which can improve motor function and promote rehabilitation in HSCT patients.