Objective To explore the effect of an on-demand rehabilitation program WeChat official accounts in home-based training of post-arthroscopy patients. Methods A total of 63 arthroscopy surgery patients from January to March 2023 were selected as a control group, and the other 65 arthroscopy surgery patients from April to June 2023 were selected as an intervention group. The control group received routine follow-up, while the intervention group was followed up for home rehabilitation by using an on-demand rehabilitation program WeChat official accounts. This software included four application modules (information profile, intervention guidance, interactive consultation, and motivation), and different levels of permissions were set based on the management hierarchy to provide continued rehabilitation nursing intervention for post-arthroscopy patients. Results A total of 60 patients completed the study in each group. At 1 month and 3 months after surgery, the compliance of home-based trainingand patient activation in the intervention group were significantly better than those in the control group (all P<.0.05.). At 3 months after surgery, the scores of upper extremity function and lower extremity function evaluation in the intervention group were significantly better than those in the control group (all P<0.05). The overall score of usability rating of the system in the intervention group was 4.30±0.57, indicating good usability. Conclusion Application of the on-demand rehabilitation program WeChat official accounts can provide continuous, full process, and real-time health services for post-arthroscopy patients, improve their compliance of home-based rehabilitation training and promotelimb function recovery.