Objective To explore the effect of family participatory multi-sensory stimulation on delirium in mechanically ventilated ICU patients. Methods A total of 80 mechanically ventilated ICU patients were divided into a control group （41 cases） and an experimental group （39 cases）. The control group received routine care,while the experimental group additionally received family participatory multi-sensory stimulation programme for delirium prevention and treatment.Results Thirty-six patients in each group completed the study. After the intervention, the incidence of delirium, the duration of delirium and the time of mechanical ventilation in the experimental group were significantly lower or shorter than those in the control group （all P＜0.05）, and the subscale scores of the information, reassurance and acceptance of the family satisfaction questionnaire in the experimental group were signi-ficantly higher than those in the control group （all P＜0.05）. Conclusion Family participatory multi-sensory stimulation can effectively reduce the incidence of delirium, shorten the duration of mechanical ventilation in mechanically ventilated ICU patients, and improve the satisfaction of patients′ family members.