Objective To analyze the relationship and interaction mechanism of fertility pressure, perceived partner responsiveness, and family resilience in female infertility patients and their spouses, and to provide basis for clinical intervention.Methods Convenience sampling was used to select 213 female patients with infertility and their spouses.The patients and their spouses were surveyed by the Fertility Problem Inventory (FPI), Perceived Partner Responsiveness Scale (PPRS), and Family Resilience Assessment Scale (FRAS).The relationship and mechanism of fertility pressure, perceived partner responsiveness, and family resilience in female infertility patients and their spouses were analyzed by the actorpartner interdependence model (APIM).Results The fertility pressure scores of female infertility patients was significantly higher than their spouses′, while the perceived partner responsiveness and family resilience scores were significantly lower than their spouses′ （all P＜0.05）.The APIM showed that in the subject effect, both the patients and their spouses′ fertility pressure had negative predictive value for their own family resilience, while the patients and their spouses′ perceived partner responsiveness had positive predictive value for their own family resilience （both P＜0.05）.In the object effect, the fertility pressure of patients and their spouses had a negative predictive value on each other′s family resilience, while the perceived partner responsiveness of spouses had a positive predictive value on the patients′ family resilience （both P＜0.05）.The mediating effect model showed that the perceived partner responsiveness mediates the relationship between fertility pressure and family resilience in the patients and their spouses, and the mediating effects were significant （all P＜0.05）.Conclusion The family resilience of female infertility patients and their spouses is closely related to each other′s fertility pressure and perceived partner responsiveness.Therefore, measures should be developed from the perspective of couple as a whole to improve their family resilience.