Objective To investigate the status of pain duration in children with growing pains (GP), to analyze the influencing factors，and to provide a reference for nursing staff to carry out targeted health guidance. Methods Totally，748 children with GP were included. Participants′ caregivers were surveyed utilizing a general information questionnaire and a self-made questionnaire on the manifestation and influencing factors of children with GP. Results The survey had 730 valid questionnaires.Among the 730 children with GP, 464 (63.56%) experienced pain duration ＜30 minutes each time, and 266 (36.44%) reported pain duration ≥30 minutes. Multivariate analysis showed that age, physical activity >60 minutes on the day of GP occurrence, asocialness were risk factors for pain duration ≥30 minutes, while vitamin D supplementation and hot compress after GP occurrence were protective factors (all P<0.05). Conclusion The pain duration in children with GP is usually no more than 30 minutes, and it can be affected by physical exercise, psychological behavioral problems, and the coping style of caregivers. Nursing staff should utilize exercise guidance and cognitive behavioral therapy to help children manage pain, improve the disease cognition level of caregivers, encourage them to take individualized intervention, in an effort to shorten the pain duration, and improve the pain experience of children with growing pain.