Objective To investigate the level of home care readiness of caregivers of patients with chronic heart failure at discharge from the hospital, to analyze its influencing factors, and to provide reference for targeted intervention.Methods A total of 221 caregivers of patients with chronic heart failure in a tertiary care hospital in Bengbu city were surveyed using a general information questionnaire, the Caregiver Home Care Readiness Scale, the Family APGAR Index （APGAR）, and the Positive Aspects of Caregiving （PAC）. Results The participants scored 51.96±11.47 for home care readiness, 6.80±2.04 for family function, and 32.61±5.67 for positive caregiving experience.Multiple linear regression analysis showed that caregiver′s education background, length of caregiving, number of other caregivers, family function, and positive caregiving experience were the main factors influencing caregivers′ home care readiness （all P＜0.05）. Conclusion Home care readiness of caregivers of patients with chronic heart failure is at a moderate level and needs to be improved.Healthcare professionals should adopt targeted interventions based on the influencing factors to improve caregivers′ home care readiness, which may contribute to better health outcomes in both patients and caregivers.