Objective To investigate the status and factors associated with kinesiophobia in patients with arteriosclerosis obliterans (ASO) of the lower limbs, and to provide reference for targeted intervention.Methods A total of 136 patients with ASO of the lo-wer limbs hospitalized in the department of vascular surgery were surveyed using a general information questionnaire, the Tampa Scale for Kinesiophobia, the Visual Analogue Scale (VAS), the Short Physical Performance Battery (SPPB) and the Medica Co-ping Modes Questionnaire (MCMQ).Results The score of kinesiophobia in ASO patients was （41.95±11.66）, and the incidence of kinesiophobia was 55.15%.Multiple linear regression analysis showed that age, VAS score, lower limb functional performance, and medical coping modes were the main influencing factors for kinesiophobia in ASO patients （all P＜0.05）.Conclusion The incidence of kinesiophobia is relatively high in ASO patients.Medical staff should formulate targeted interventions according to the influencing factors to reduce the occurrence of kinesiophobia in patients.