Objective To explore the effect of positive psychological intervention combined with multimodal exercise in patients receiving chemotherapy for breast cancer.Methods Totally, 360 breast cancer patients hospitalized for chemotherapy were assigned to a control group or an observation group, with 180 in each group.The control group was subjected to routine chemotherapy care, while the observation group additionally received positive psychological intervention combined with multimodal exercise.Both groups received 3 courses of chemotherapy, and the effect was evaluated after 12 weeks of intervention.Results After the intervention, the observation group had significantly higher scores of hope and confrontation, whereas significantly lower scores of avoi-dance, acceptance-resignation, and cancer-related fatigue than those in the control group （all P＜0.05）.The blood CD3+ and CD4+ T cell levels and CD4+/CD8+ ratio were significantly better in the observation group than those in the control group （all P＜0.05）.Conclusion Combination use of positive psychological intervention and multimodal exercise can improve patients′ mental health and coping style, ameliorate fatigue and enhance immune function.