Objective To develop a questionnaire to evaluate the demand for community medical-nursing combined services among urban empty-nest older adults and to test its reliability and validity.Methods Based on the Maslow′s Hierarchy of Needs theory and the Active Aging theory, a draft of the questionnaire was formulated after literature review, qualitative interviews, and expert consultation, then a cross-sectional survey with 495 urban empty-nest older adults was conducted to test the reliability and validity of the questionnaire.Results The final version of the questionnaire included eight dimensions and 37 items, which accounted for 65.559% of the total variance in exploratory factor analysis. The item-level content validity index (CVI) ranged from 0.824 to 1.000, and the scale-level CVI was 0.930.The overall Cronbach′s α coefficient was 0.966.Confirmatory factor analysis indicated good model fit （χ2/df = 1.236,RMSEA=0.033,SRMR=0.030,CFI= 0.982,TLI=0.980,IFI=0.982）.Conclusion The questionnaire is reliable and valid to assess demand for community medical-nursing combined services among urban empty-nest older adults.