Objective To explore the effectiveness of acceptance commitment group therapy (ACT-G) for patients with inflammatory bowel disease (IBD).Methods Ninety-three patients with IBD were assigned to a control group of 46 and an intervention group of 47 chronologically.Both groups were subjected to conventional treatment and care, and the intervention group additionally received ACT-G for 8 consecutive weeks.Effect was measured before, immediately after, and one month after the intervention.Results Forty-three cases in both groups completed the study.Acceptance of illness, anxiety, self-management ability, and Crohn′s disease activity scores in the intervention group were significantly better than those in the control group after the intervention （all P＜0.05）.Conclusion ACT-G for patients with IBD can effectively alleviate their negative mindset, enhance self-care ability and promote di-sease mitigation.