Objective To summarize the best evidence regarding exercise intervention for patients receiving non-surgical treatment for knee osteoarthritis，and to provide a basis for clinical exercise rehabilitation of these patients. Methods The clinical questions in need of evidence-based problem-solving approach were determined. According to the "6S" evidence model, all evidence on exercise intervention for patients receiving non-surgical treatment for osteoarthritis of the knee in domestic and international databases/websites，such as JBI′s EBP database，the BMJ，and National Institute for Health and Care Excellence (NICE)，was searched by computer. The types of literature included guidelines，systematic reviews，evidence summaries，expert consensus reports，and clinical decisions，randomized controlled trials，and the search time frame was limited from 10 February 2018 to 10 February 2023. Literature quality assessment，evidence extraction，and summarization were conducted independently by 2 researchers. Results A total of 12 publications (including 6 guidelines, 2 systematic reviews, 2 expert consensus reports and 2 randomized controlled trials) were retrieved. A total of 27 pieces of best evidences were summarized into 6 aspects，including exercise principles，exercise assessment, exercise types, exercise intensity, exercise frequency and duration, and exercise monitoring. Conclusion The development of exercise programs for patients with osteoarthritis of the knee should follow the principles of frequency, intensity, duration and type of exercise, and healthcare professionals should take into account such factors as patient′s own wishes, the scenarios of evidence application before developing individualized exercise intervention plan for these patients.