Objective To observe the effect of different moxibustion temperatures on wound repair in rats with pressure injury. Methods Sixty-five SPF SD male rats were selected and 60 of them were subjected to perform pressure ulcer modeling according to the principle of ischemia-reperfusion. Upon successful modeling, the rats were randomly divided into 1 model group, and 3 moxibustion groups ［the (42±1)℃ group, the (45±1)℃ group and the (48±1)℃ group］, with 15 rats in each group. The wound of the model group was disinfected with iodophor once a day for 12 days. Moxibustion groups were treated with moxibustion using moxa sticks with a diameter of 18 mm at varied temperatures, 10 min each time, once a day, for 12 days. On the 3rd, 7th and 10th day of intervention, wound healing, healing time, healing rate and pathological changes of the four groups were observed and compared, and the expression levels of vascular endothelial growth factor A (VEGF-A), HIF-1α and p-Akt were observed. Results On the 3rd, 7th and 10th day of intervention, the wound healing time of moxibustion groups was significantly shorter than that of the model group;the wound healing time of the (45±1)℃ group was shorter than that of the (42±1)℃ group and the (48±1)℃ group; the wound healing rate of the (45±1)℃ group was higher than that of the (42±1)℃ group and the (48±1)℃ group (all P<0.05). The results of HE staining showed that the number of inflammatory cells in the (45±1)℃ group were less than the other groups, the new granulation tissue was more than the other groups, and the vascular endothelial cells and fibroblasts were more closely arranged. Immunohistochemical results showed that the expression levels of VEGF-A, HIF-1α and p-Akt in moxibustion groups were higher than those in the model group on the 3rd and 7th day of intervention (all P<0.05). Compared with the (42±1)℃ group and the (48±1)℃ group, the expression levels of VEGF-A, HIF-1α and p-Akt in the (45±1)℃ group were higher (all P<0.05). On the 10th day of intervention, the expression levels of VEGF-A and p-Akt in the (45±1)℃ group were higher than those in the other groups (all P<0.05). Conclusion Moxibustion at (45±1)℃ could promote wound healing, shorten the healing time, and improve repair effect.