Objective To systematically retrieve, evaluate, and synthesize the best evidence regarding management of tumor associated ascites drainage with a central venous catheter (CVC). Methods Such databases such as UptoDate, BMJ Best Clinical Practice, JBI Evidence-Based Health Care Center database, PubMed, Cochrane Library, MedLive, and CNKI, were searched for guidelines, systematic reviews, expert consensus reports, clinical decisions, and randomized controlled trials on continuous drainage of tumor-associated ascites with a CVC. Two researchers conducted quality appraisal of the included literature, extracted necessary information, and utilized professional judgment to summarize the evidence. Results Totally，12 papers, including 1 clinical decision, 3 expert consensus reports, 1 systematic review, 6 randomized controlled trials, and 1 cohort study, were included, yielding 23 pieces of evidence in CVC drainage for tumor associated ascites factored into 9 aspects:assessment, tweaking device for ascites drainage, catheter fixation, dressing, flushing and sealing, management of catheter blockage, prevention and management of ascites leakage, complication management and health education. Conclusion The best evidence regarding management of tumor associated ascites drainage with a CVC, could provide evidence-based support for clinical workers to perform the procedure, and optimize drainage management.