Objective To understand fatigue experience and coping strategies of patients with post-stroke fatigue, so as to provide a reference for developing tailored nursing plans.Methods A descriptive qualitative study was designed, and 16 individuals with post-stroke fatigue were selected using purposive sampling method, then semi-structured interviews were conducted on them, at last, the interview data were analyzed and categorized using thematic analysis.Results Four themes on fatigue experience were extracted:the distinctive characteristics of post-stroke fatigue, the disruption of daily life, the feedback of discussing fatigue with others, and the desire for support and understanding.Two themes emerged from the strategies patients used to cope with fatigue:proactive efforts to overcome and adjust to fatigue, the inclination to escape or abandon managing fatigue.Conclusion Medical staff should pay attention to screening and assessing post-stroke fatigue, encourage patients to cope with fatigue positively, and take comprehensive intervention through various channels to relieve fatigue symptom.