Objective To explore the effect of a nursing intervention based on the Solution-focused Brief Therapy (SFBT) on adolescents with depression.Methods A total of 60 adolescents with depression were divided into a control group and an intervention group according to their wards, with 30 cases in each group.Both groups were treated with conventional antidepressant therapy, and the control group received routine nursing during hospitalization, while the intervention group received a nursing intervention based on the SFBT.Results After the intervention, the scores of the Self-rating Anxiety Scale (SAS), the Self-rating Depression Scale (SDS), the Ruminative Responses Scale (RRS), the Non-suicidal Self-Injury (NSSI), and the Positive and Negative Suicide Ideation (PANSI) in the intervention group were significantly lower than those in the control group, while its two subscale scores of resource utilization and goal orientation in the Solution-focused Inventory(SFI) were significantly higher than those of the control group (all P＜0.05).Conclusion The nursing intervention based on the SFBT is beneficial to alleviate anxiety and depression for adolescents with depression, reduce their level of rumination and non-suicidal self-injurious behaviors and suicidal ideation, and improve their recovery confidence.