Objective To evaluate the management effect of TCM chronic disease nursing clinic in endometriosis oupatients.Methods The historical control method was used, a total of 88 endometriosis outpatients with dysmenorrhea after laparoscopic surgery from January to December 2020 were regarded as a control group, who received routine postoperative outpatient visit and follow-up, and their counterparts of 88 patients visited from January to December 2021 were taken as an experimental group, who additionally received TCM chronic disease management in a nurse-led clinic for 3 months.The intervention effect was evaluated at 3,6, and 12 months after the intervention.Results Totally 85 patients in each group completed the study and follow-up.When compared the dysmenorrhea score, self-management ability score and quality of life score between the two groups, the intervention effect, time effect and intervention × time effect were statistically significant (all P＜0.05).Conclusion The TCM chronic disease nursing cli-nic management in endometriosis outpatients, can more effectively alleviate the symptom of dysmenorrhea, and improve patients′ disease self-management ability and quality of life.